Our Office is nearest to you Not your office?

SGF Presents Key Findings at ASRM Annual Meeting

Through our commitment to research, Shady Grove Fertility strives to increase both safety and success for patients undergoing fertility treatments

At the 2015 American Society for Reproductive Medicine’s (ASRM's) Annual Meeting, physician scientists from Shady Grove Fertility presented four oral abstract presentations and 10 poster presentations. The theme of this year's premier education and research meeting for reproductive medicine was 'Steering Reproductive Medicine to the Forefront of Global Public Health.' Three of the notable studies Shady Grove Fertility presented at this year’s ASRM meeting included:

FETs Improve Success Rates when Progesterone Levels are Elevated

Frozen Embryo Transfer (FET) improves success of embryos derived from in vitro fertilization (IVF) cycles where Progesterone levels are elevated.

Shady Grove Fertility researchers evaluated a total of 4,124 IVF treatment cycles to determine whether the detrimental effect of high progesterone levels at the time of the “trigger” shot—the final phase of stimulation during IVF treatment—was ameliorated by freezing all the embryos for transfer in a subsequent FET cycle. When progesterone was elevated during stimulation, subsequent FET was over 10 times more likely to result in pregnancy than transfer of fresh embryos immediately following ovarian stimulation. In addition, no differences in outcomes were seen between FETs of embryos generated from IVF cycles with elevated progesterone versus from cycles with normal progesterone levels.

What this means for patients
The study validated the practice of freezing good quality embryos in cycles where progesterone levels are elevated during stimulation for IVF. Subsequent FET to a more receptive uterus, unaffected by elevated progesterone levels, may increase pregnancy rates by as much as 50 percent.

sperm COUNT correlated with iui pregnancy rates

The number of moving sperm in the sample used for intrauterine insemination (IUI) correlated with chance of pregnancy up to a threshold of 9 million total motile sperm (TMS).

The analysis of 47,500 IUI cycles showed that after sperm wash for IUI, if total motile sperm count was 9 million, the chances of a clinical pregnancy per IUI was approximately 17 percent. If the sample used for IUI contained 9 million, 10 million, or 20 million moving sperm, success rates did not increase further. However, for patients with fewer than 9 million moving sperm in the IUI sample, chances of pregnancy decreased as the counts decreased, to the point that when the sample contained fewer than 1 million moving sperm, there was a less than 5 percent chance of pregnancy.

What this means for patients
Based on the findings, physicians can now counsel patients about their potential success rates with IUI and whether it is the right initial treatment option for them. Furthermore, this data suggest that when a baseline semen analysis shows a borderline sperm count, patients may benefit from a diagnostic sperm wash to obtain a more accurate prediction of the total motile sperm count that would be available for IUI treatment, and thereby obtain a refined understanding of success rates.

Pregnancy outcomes using eggs frozen are as good as with ‘fresh’ eggs

Pregnancy outcomes of IVF using women’s own eggs frozen for fertility preservation were as good as IVF with ‘fresh’ eggs.

The largest published data set on IVF at Shady Grove Fertility reports on the outcomes of women who froze their own eggs and then later used them in the hopes of achieving pregnancy. The study showed that fresh and frozen eggs (when vitrification technology was used) yielded similar chances of success. Specifically, the rates of fertilization, implantation, pregnancy, and birth were all as high among women who used vitrified eggs as in women who used fresh eggs.

What this means for patients
This data suggests that egg freezing, regardless of the reason, is a viable way for women to preserve their fertility. In addition, physicians can use this information to reassure couples who need to freeze eggs unexpectedly and those who freeze eggs intentionally to limit the number of embryos created. These couples can rest assured that their chance of success will not be impaired by using frozen eggs.

Recently Visited Pages

The following mark the 9 most recent pages you have visited on ShadyGroveFertility.com. Please click a link below to return to that page.