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Melissa A.Esposito, M.D.

Board Certified

  • Obstetrics and Gynecology
  • Reproductive Endocrinology and Infertility
2005 Technology Pkwy, Building 2
Suite 340
Mechanicsburg, PA 17050
10630 Little Patuxent Parkway
Suite 305
Columbia, MD 21044
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About melissa a. esposito, M.D.

Melissa A. Esposito, M.D., earned her medical degree from the University of Medicine and Dentistry of New Jersey and completed her residency training in obstetrics and gynecology from the University of Connecticut Health Center. She completed a 3-year fellowship program in reproductive endocrinology and infertility at the University of Pennsylvania. She is board certified in obstetrics and gynecology and reproductive endocrinology. Dr. Esposito is a member of the American Society for Reproductive Medicine and the American Congress of Obstetricians and Gynecologists.

Throughout her career, Dr. Esposito has been the recipient of numerous awards and honors from the American Medical Women’s Association, the Philadelphia Area Reproductive Endocrine Society, and the American Association of Gynecologic Laparoscopists, among others. Aside from her clinical practice, Dr. Esposito is also actively involved in teaching the medical students at Georgetown University School of Medicine in the department of obstetrics and gynecology, Division of Reproductive Endocrinology and Infertility.

  • Residency: Obstetrics and Gynecology, University of Connecticut Health Center
  • Fellowship: Reproductive Endocrinology and Infertility, University of Pennsylvania
Professional Organizations
  • American Congress of Obstetricians and Gynecologists
  • American Society for Reproductive Medicine

Q & A

Q: Why did you become a doctor/reproductive endocrinologist (REI)?


When I was in medical school and made my final decision to do my residency in obstetrics and gynecology, I had the opportunity to do a rotation with the REI department during my fourth year of medical school. The faculty was so amazing, as were the fellows that I got to shadow and work with, that I became inspired to go into the field. I loved the fact that as infertility specialists we make such a huge and positive impact in our patients' lives, while getting to practice medicine in a field that is always dynamic, exciting, and continuously evolving.

Q: Who inspires you?


I’ve been fortunate enough to have been inspired by many people in my life who have positively affected me in many ways! I’ve been inspired by exemplary teachers and mentors during my medical training, but especially during my subspecialty training, who through their dedication to this field and their patients demonstrated what being a great doctor really means! I’m also inspired by those in my life who give back to society through philanthropic and charitable acts of great kindness and sacrifice, by serving and helping the less fortunate, because like them, I believe strongly that we are all called to give back to society in some fashion. I have been inspired by my parents, who have bestowed upon me my steadfast work ethic and drive and sacrificed so much to be sure that I was able to get to college and medical school. I am always inspired by patients who persevere in their quest to become parents, when that goal can seem so difficult, yet remain optimistic and kind through it all!

Q: What about SGF makes you the most proud?


I feel that we strive to always give the best patient care and practice very ethical medicine, in a field where that can be challenging and at times fraught with ethical dilemmas.

Q: What’s on your bucket list?


I have many destinations on my travel bucket list that I’m waiting to see until I retire because they will require a long visit. I also sponsor a classroom of children in India from the slums who attend a private school that is funded by corporate and private sponsors. I went to meet my children and their families last year and it was one of the best trips I’ve ever been on! I would love to be able to go to the school every year and volunteer for a month or so once I retire because I was so impressed with the school, the children, and the wonderful educators who have dedicated their lives to these children! These children are so happy and so smart, but more importantly so grateful for the chance to be able to attend school and improve their lives. Being even a small part of something so special makes me a better person!

Q: What is your approach to helping patients who are struggling?


When I know that a patient is struggling, I think it's important to acknowledge and validate that they are struggling. I think it's important to acknowledge that what they’re feeling is not unusual. I let them know that I understand that they are having a difficult time and to reiterate that I am here for them and will do what I can to help them. Just taking an extra few minutes during the consult, sending a card, or giving the patient a call goes a long way!

I am always inspired by patients who persevere in their quest to become parents, when that goal can seem so difficult, yet remain optimistic and kind through it all!


"Dr. Esposito helped us fulfill our dreams of becoming parents. She is so compassionate and sensitive to your feelings and wants. She is realistic and offers her best recommendations, always. I can't thank her and all of the staff at Shady Grove Fertility enough. We will definitely be back when we're ready for baby #2."

"My husband and I are former patients of Shady Grover Fertility. We had the best experience from start to finish. Dr. Esposito and the entire Shady Grove Fertility team was dedicated to helping us start our family and I would highly recommend them to anyone having trouble conceiving or even looking for some general advice. They truly made the experience painless and we now have a beautiful little boy because of them! I am truly grateful that we found Shady Grove Fertility!"

"For 4 years my husband and I tried to get pregnant. Traditional Chinese medicine, acupuncture, chiropractic, gluten free diet, medicated cycles, IUI’s and IVF led to month after month of disappointment. We went to an education session offered by Shady Grove Fertility and met Dr. Esposito and scheduled an appointment. In less than a year we were finally pregnant and now have a beautiful daughter who will be 1 soon! The entire staff at Shady Grove Fertility are amazing and we wish we would have went sooner."

"Dr. Esposito and the Shady Grove Fertility staff our wonderful and ease the stressful process of infertility. I went through a tough journey, totaling 3 IUIs and 4 IVFs, but wouldn’t have traded any of that long and tough battle because we ended up with terrific twin sons!! We’re presently back to hopefully complete our family with one more child. Dr. Esposito and her staff comforted me and my wife along the way and definitely made a very trying time a lot more manageable!! Thank you!"

"Dr. Esposito gave me confidence during my infertility journey when other doctors shot me down. She has a great energy about her and is very knowledgeable. After years of trying to conceive I was able to have my son after one IVF treatment. I am now back to start a second treatment, FET, and feel really hopeful since I am back under her care. Thanks for everything Dr. Esposito!!"

"Dr. Esposito and the staff at Shady Grove Fertility are AMAZING! They are informative, patient, kind, efficient, and just all around fantastic. We have them to thank for our son, which is the best thing that has ever happened to us. I recommend them to everyone that I know struggling with fertility and will go back myself when we are ready for another baby. We could never thank Dr. Esposito and the rest of the staff enough for making our dreams come true!"

"My husband and I liked Dr. Esposito from the first time we met her during our consultation. She was personable, confident in her knowledge as a professional, and gave us hope when we were at our most vulnerable. Dr. Esposito and her team helped us conceive our son in 2014, and our daughter in 2016. She was both honest and supportive throughout the entire process. I remember she even called me on a Saturday afternoon to discuss our treatment plan. I cannot recommend Dr. Esposito and the Shady Grove Fertility Frederick office staff enough...they were there through it all."

"Thank you so much for last week’s consultation. Your kindness, enthusiasm and compassion were so appreciated. Although we’re thinking positive thoughts and hoping for the best, what’s most important is that you treated me so much nicer than just numbers on a scale. Thank you for that! It’s not often that you happen upon such kindness. Thank you."

"I felt a strong need to thank you personally for all your support throughout the whole process. I was impressed by your ability to maintain professionalism while displaying genuine compassion. Working in the health field myself, I know it is not always easy to work with clients who are under such emotional stress. However, we felt everyone in your office were always patient, kind and understanding. It meant a lot when you were willing to extend the treatment after all our medical setbacks. You and your team touched our hearts deeply. You all made a very stressful journey bearable and we thank all of you for everything. I will continue to refer people to you with confidence. We were blessed to meet all of you!! Thanks again for the opportunity and the utmost of care."

"After seven years of trying to conceive, my husband and I were feeling very weary and at breaking point. During our very first appointment with Dr. Esposito, she sat with us for over an hour just listening to our hopes, dreams, and frustrations. I remember the office closed and she told the office staff to go home, then sat with us and listened while she worked out a plan for us. It was only a few months of treatment before we found out we were pregnant. I still cannot believe it! We love her!!!!"



  • Esposito MA, Coutifaris C, Barnhart KT. A moderately elevated day 3 FSH level has limited predictive value, especially in younger women. Hum Reprod. 2002;17(1):118-123.
  • Esposito M, Barnhart KT, Coutifaris C, Patrizio P. The role of peri-ovulatory LH during ART cycles stimulated exclusively with recombinant FSH. Fertil Steril. 2001;75(3):519-24.
  • Barnhart KT, Coutifaris C, Esposito M. The pharmacology of methotrexate. Expert Opinion in Pharmacotherapy. 2001;2(3):409-17.
  • Esposito M, and Patrizio P. Double follicular aspiration can save an IVF cycle after improper administration of hCG. J Reprod Med. 2000;45(6):511-14.
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