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Melissa A.Esposito, M.D.

Board Certified

  • Obstetrics and Gynecology
  • Reproductive Endocrinology and Infertility
2005 Technology Pkwy, Building 2
Suite 340
Mechanicsburg, PA 17050
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About melissa a. esposito, M.D.

Melissa A. Esposito, M.D., received her medical degree from the University of Medicine and Dentistry of New Jersey and her residency training in obstetrics and gynecology from the University of Connecticut Health Center. She completed a 3-year fellowship program in reproductive endocrinology and infertility at the University of Pennsylvania. She is board certified in obstetrics and gynecology and reproductive endocrinology. Dr. Esposito is a member of the American Society for Reproductive Medicine and the American Congress of Obstetricians and Gynecologists.

Throughout her career, Dr. Esposito has been the recipient of numerous awards and honors from the American Medical Women’s Association, the Philadelphia Area Reproductive Endocrine Society, and the American Association of Gynecologic Laparoscopists, among others. Aside from her clinical practice, Dr. Esposito is also actively involved in teaching the medical students at Georgetown University School of Medicine in the department of obstetrics and gynecology, Division of Reproductive Endocrinology and Infertility.

  • Residency: Obstetrics and Gynecology, University of Connecticut Health Center
  • Fellowship: Reproductive Endocrinology and Infertility, University of Pennsylvania
Professional Organizations
  • American Congress of Obstetricians and Gynecologists
  • American Society for Reproductive Medicine

Q & A

Q: Why did you become a doctor/reproductive endocrinologist (REI)?


When I was in medical school and made my final decision to do my residency in obstetrics and gynecology, I had the opportunity to do a rotation with the REI department during my fourth year of medical school. The faculty was so amazing, as were the fellows that I got to shadow and work with, that I became inspired to go into the field. I loved the fact that as infertility specialists we make such a huge and positive impact in our patients' lives, while getting to practice medicine in a field that is always dynamic, exciting, and continuously evolving.

Q: Who inspires you?


I’ve been fortunate enough to have been inspired by many people in my life who have positively affected me in many ways! I’ve been inspired by exemplary teachers and mentors during my medical training, but especially during my subspecialty training, who through their dedication to this field and their patients demonstrated what being a great doctor really means! I’m also inspired by those in my life who give back to society through philanthropic and charitable acts of great kindness and sacrifice, by serving and helping the less fortunate, because like them, I believe strongly that we are all called to give back to society in some fashion. I have been inspired by my parents, who have bestowed upon me my steadfast work ethic and drive and sacrificed so much to be sure that I was able to get to college and medical school. I am always inspired by patients who persevere in their quest to become parents, when that goal can seem so difficult, yet remain optimistic and kind through it all!

Q: What about SGF makes you the most proud?


I feel that we strive to always give the best patient care and practice very ethical medicine, in a field where that can be challenging and at times fraught with ethical dilemmas.

Q: What’s on your bucket list?


I have many destinations on my travel bucket list that I’m waiting to see until I retire because they will require a long visit. I also sponsor a classroom of children in India from the slums who attend a private school that is funded by corporate and private sponsors. I went to meet my children and their families last year and it was one of the best trips I’ve ever been on! I would love to be able to go to the school every year and volunteer for a month or so once I retire because I was so impressed with the school, the children, and the wonderful educators who have dedicated their lives to these children! These children are so happy and so smart, but more importantly so grateful for the chance to be able to attend school and improve their lives. Being even a small part of something so special makes me a better person!

Q: What is your approach to helping patients who are struggling?


When I know that a patient is struggling, I think it's important to acknowledge and validate that they are struggling. I think it's important to acknowledge that what they’re feeling is not unusual. I let them know that I understand that they are having a difficult time and to reiterate that I am here for them and will do what I can to help them. Just taking an extra few minutes during the consult, sending a card, or giving the patient a call goes a long way!

I am always inspired by patients who persevere in their quest to become parents, when that goal can seem so difficult, yet remain optimistic and kind through it all!


"Dr. Esposito helped us fulfill our dreams of becoming parents. She is so compassionate and sensitive to your feelings and wants. She is realistic and offers her best recommendations, always. I can't thank her and all of the staff at SGF enough. We will definitely be back when we're ready for baby #2."

"My husband and I are former patients of Shady Grover Fertility. We had the best experience from start to finish. Dr. Esposito and the entire Shady Grove team was dedicated to helping us start our family and I would highly recommend them to anyone having trouble conceiving or even looking for some general advice. They truly made the experience painless and we now have a beautiful little boy because of them! I am truly grateful that we found Shady Grove Fertility!"

"For 4 years I my husband and I tried to get pregnant. Traditional Chinese medicine, acupuncture, chiropractic, gluten free diet, medicated cycles, IUI’s and and IVF led to month after month of disappointment. We went to an education session offered by Shady Grove and met Dr. Esposito and scheduled an appointment. In less than a year we were finally pregnant and now have a beautiful daughter who will be 1 soon! The entire staff at Shady Grove are amazing and we wish we would have went sooner."

"Dr. Esposito and the Shady Grove Staff our wonderful and make it a little bit easier while going through infertility. I went through a tough journey, totaling 3 IUIs and 4 IVFs, but wouldn’t have traded any of that long and tough battle because we ended up with terrific twin sons!! We’re presently back to hopefully complete our family with one more child. Dr. Esposito and her staff comforted me and my wife along the way and definitely made a very trying time a lot more manageable!! Thank you!"

"Dr. Esposito gave me confidence during my (in)fertility journey when other Dr's shot me down. She has a great energy about her and is very knowledgeable. After years of trying to conceive I was able to have my son after one IVF treatment. I am now back to start a second treatment, FET, and feel really hopeful since I am back under her care. Thanks for everything Dr. E!!"

"Dr. Esposito and the staff at Shady Grove are AMAZING! They are informative, patient, kind, efficient, and just all around fantastic. We have them to thank for our son, which is the best thing that has ever happened to us. I recommend them to everyone that I know struggling with fertility and will go back myself when we are ready for another baby. We could never thank Dr. Esposito and the rest of the staff enough for making our dreams come true!"

"When we finally got to the part of our fertility journey that we needed even more help, we are so thankful that it was Dr. Esposito at the end of that journey. From the initial consultation through every step forward and back she was there for us with knowledge, guidance and caring. We had been through other fertility centers and when we found Shady Grove we had just about given up. With Dr. Esposito (and the staff in Frederick) we felt cared for and listened to each and every time. I'm writing this review 10 years after our first consultation with Dr. Esposito and still remember her with the same emotion as those office visits. Happiness that she helped us to become parents. We didn't have every outcome that we desired along the way, but we are still so very thankful for her."

"My husband and I liked Dr. Esposito from the time we met her for our first consultation. She was personable, confident in her knowledge as a professional, and gave us hope when we were at our most vulnerable. Dr. Esposito and her team helped us conceive our son in 2014, and our daughter in 2016. She was both honest and supportive throughout the entire process. I remember she even called me on a Saturday afternoon to discuss our treatment plan. I cannot recommend Dr Esposito and the SGF Frederick office staff enough...they were there through it all."

"From the very beginning, I felt like Dr. Esposito really listened to me and was really rooting for me. I spent 15 months with my regular gyn trying to get pregnant and I never felt like she listened to my concerns or cared if I ever got pregnant -- I felt like she just thought I was being impatient. But Dr. Esposito really listened and took steps to address the things I was concerned about. I never felt rushed, I never felt like she thought I was asking dumb questions. Plus, she was so friendly and funny -- I thought I would need tissues at our first appointment, but I've never laughed so much in a doctor's office! Dr. Esposito is probably my favorite of every doctor I have ever seen for anything."

"Thank you so much for last week’s consultation. Your kindness, enthusiasm and compassion were so appreciated. Although we’re thinking positive thoughts and hoping for the best, what’s most important is that you treated me so much nicer than just numbers on a scale. Thank you for that! It’s not often that you happen upon such kindness. Thank you."

"Thank you for the kind and compassionate care we have received at your practice. We truly appreciate all that you have done for us."

"I felt a strong need to thank you personally for all your support throughout the whole process. I was impressed by your ability to maintain professionalism while displaying genuine compassion. Working in the health field myself, I know it is not always easy to work with clients who are under such emotional stress. However, we felt everyone in your office were always patient, kind and understanding.
It meant a lot when you were willing to extend the treatment after all our medical setbacks. Your upbeat personality was contagious and uplifting. I could go on and on about how great each one of you are but I know you time is valuable and limited. The main point is: You and your team touched our hearts deeply. You all made a very stressful journey bearable and we thank all of you for everything. I will continue to refer people to you with confidence.
We were blessed to meet all of you!! Thanks again for the opportunity and the utmost of care."

"First, I wanted to thank all of you for being such wonderful people. Our choice to come to Shady Grove was an easy one for all of the praise you had received. We had no idea what was in our future, but we know that we would have options that we wouldn’t necessarily have in PA…we were blessed in many ways. We were able to meet all of you and were able to learn of different options that are out there for couples who are having fertility issues. I have recommended you to my friends that have been having difficulties. Please know that you played a pivotal part in our journey to becoming parents, our dream has come true. With admiration for what you do and who you are."

"My husband and I had been trying to conceive for 15 years. We did infertility treatments on and off all that time. We met with Dr. Esposito and she gave us so much hope. We got pregnant our first IVF cycle. Our daughter is 11 months now and we are awaiting results of our pregnancy test next week for baby #2 and maybe #3. I cannot praise them enough for making our dreams come true."

"I cannot recommend Dr. Esposito and Shady Grove Fertility enough! After 14 months of trying to get pregnant with no success, we met with Dr. Esposito and she was very thorough in her review and recommendations based on our case. She was timely in all of her responses, she answered any and all questions my spouse or I had, and she went above and beyond to share reassurance and comfort during the most frustrating times of infertility. She is a caring and compassionate person who is excellent at her job. I know a number of women who have had success under her care. I'll always remember that she called me just to update me on things, and even just to wish me luck before my procedures. She's not only an excellent practitioner, she is a delightful person as well who really cares about her patients and will do whatever is in her power to see them succeed."

"Shady Grove Fertility and Dr. Esposito provided exceptional and thorough care in my (and my husband's) journey through infertility. I am also in healthcare and understand the time crunch and numerous patients' issues to deal with, but never felt like I was "just a number" with Dr. Esposito. Her and the Shady Grove staff (especially Tracey) were informative, timely, truly concerned, and compassionate at each step. They provided reassurance when I had doubts and were my cheerleaders throughout!"

"Seven years of trying to conceive. My husband and I were feeling very weary and at breaking point. Our very first appointment with Dr. Esposito she sat with us for over an hour just listening to our hopes, dreams, and frustrations. I remember the office closed and she told the office staff to go ahead and go home and she sat with us and listened and worked out a plan for us. It was only a few months of treatment before we found out we were pregnant. I still cannot believe it! We love her!!!!"

"After seeing many specialists we considered adoption, but something just didn't feel right. We made an appointment with Dr. Esposito at the Camp Hill location to talk to one more physician. It was the best decision we ever made. From the moment we met Dr. Esposito we felt like we were in the right place for the very first time. She is so caring and supportive. She always answered our questions and made us feel like we were the most important patient she had; not just another number."

"Excellent provider. Patient, compassionate, thorough, knowledgeable, and overall a pleasure to deal with. We conceived under her care without problems. We can tell she enjoys helping others."

"Dr. Esposito is very knowledgeable in reproductive endocrinology and infertility. The decisions that she advised me to take all worked out very well. Throughout my IVF journey, she is always patient, kind and resourceful."



  • Esposito MA, Coutifaris C, Barnhart KT. A moderately elevated day 3 FSH level has limited predictive value, especially in younger women. Hum Reprod. 2002;17(1):118-123.
  • Esposito M, Barnhart KT, Coutifaris C, Patrizio P. The role of peri-ovulatory LH during ART cycles stimulated exclusively with recombinant FSH. Fertil Steril. 2001;75(3):519-24.
  • Barnhart KT, Coutifaris C, Esposito M. The pharmacology of methotrexate. Expert Opinion in Pharmacotherapy. 2001;2(3):409-17.
  • Esposito M, and Patrizio P. Double follicular aspiration can save an IVF cycle after improper administration of hCG. J Reprod Med. 2000;45(6):511-14.
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