Isaac E. Sasson, M.D., Ph.D.

Board Certified Board Certified

  • Obstetrics and Gynecology
  • Reproductive Endocrinology and Infertility
Patient Testimonial
I cannot express how confident I feel in recommending Dr. Sasson and his team/staff at Shady Grove Fertility. They went above and beyond to make our struggle less stressful.

Dr. Sasson makes you feel immediately comfortable and optimistic. You do not feel like a just another patient.

Dr. Sasson and his team are simply amazing! He is kind, compassionate, patient, and extremely good at what he does.

Dr. Sasson changed our lives and made our dreams come true!

Walking into our initial consultation with Dr. Sasson was like a breath of fresh air-we immediately knew we were in great hands.

They always made me feel like a priority, and they were truly invested in our success. Dr. Sasson and his team became my family.

We felt like VIPs and always wonder why other medical experiences can’t be so supportive and positive.


Isaac E. Sasson, M.D., Ph.D., FACOG, received his medical degree and doctorate in genetics from Yale Medical School. He went on to complete his residency in obstetrics and gynecology at Yale-New Haven Hospital and his subspecialty training in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania in Philadelphia.

He has expertise in the diagnosis and treatment of infertility, including in vitro fertilization, donor egg treatment, endometriosis, polycystic ovary syndrome, and preimplantation genetic diagnosis. He utilizes both his clinical experience and extensive background in genetics research to optimize patient pregnancy and live birth rates.

Dr. Sasson has been featured in many publications, including Main Line Parent, Philadelphia Life, and Suburban Life. He has also appeared on The Katie Couric Show in a segment highlighting male factor infertility and on CBS 3 Philadelphia, where he discussed technological advancements in fertility treatment.

Originally from Monmouth County, New Jersey, Dr. Sasson is married with three children and enjoys yoga, spinning, hiking, and woodworking.

Dr. Sasson is currently associate residency director of ob-gyn residents at Lankenau Hospital outside of Philadelphia. He is a member of the American Society for Reproductive Medicine, American Congress of Obstetricians and Gynecologists, Obstetrical Society of Philadelphia, and Philadelphia Area Reproductive Endocrine Society.

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I am inspired by the nursing staff at Shady Grove Fertility who are on the front line of patient care and are always working for perfection.


  • Residency: Obstetrics and Gynecology, Yale-New Haven Hospital
  • Fellowship: Reproductive Endocrinology and Infertility, University of Pennsylvania
  • Main Line Today magazine Top Doctors (2014-2015, 2023)
  • 2016 Inaugural Physicians Council Member, RESOLVE The Infertility Association
  • Suburban Life Magazine Top Physician (2016, 2024)
  • American Congress of Obstetricians and Gynecologists
  • American Society of Reproductive Medicine
  • Obstetrical Society of Philadelphia
  • Philadelphia Area Reproductive Endocrine Society
  • Sasson IE, Vitins AP, Mainigi MA, Moley KH, Simmons RA. Pre-gestational vs. gestational exposure to maternal obesity differentially programs the offspring in mice. Diabetologia.2015;58:615-624.
  • Grissom NM, Lyde R, Christ L, et al. Obesity at conception programs the opioid system in the offspring brain. Neuropsychopharmacology. 2014;39:801-810.
  • Sasson I, Mesaros C, Bartolomei MS. Bisphenol A exposure alters DNA methylation and disrupts genomic imprinting in the mouse. PLoS Genetics. 2013;9:e1003401.
  • Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, et al. Embryonic poly(A) binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochem J. 2012;446:47-58.
  • Sasson IE, Kodaman PH. Adhesion prevention in gynecologic surgery. The Female Patient. 2008;33:1-5.
  • Johnson LN, Sasson IE, Sammel MD, Dokras A. Does intracytoplasmic sperm injection improve the fertilization rate and decrease the total fertilization failure rate in couples with well-defined unexplained infertility? A systematic review and meta-analysis. Fertil Steril.2013;100:704-11.


My father is a pediatrician and the practice of medicine was always in our home. He works very hard, and growing up I always heard him on the phone with patients. He served as a role model when becoming an adult. So my connection to medicine is very connected to my family life at home.

I am inspired by my patients’ strength. I am inspired by my kids’ thirst for knowledge, love, and experience. I am inspired by my medical school classmates. I am regularly amazed at how diverse they are and how much they have accomplished. I am inspired by the nursing staff at Shady Grove Fertility who are on the front line of patient care and are always working for perfection. I am inspired by my best friend, a lawyer on Capitol Hill. He is full of energy and enthusiasm and always looking for the next meaningful life experience. I think he is acutely aware that we only live once and that we need to make the most of every single day.

I want to lie on a beach in Tahiti, dive on the Great Barrier Reef, and go on safari in Africa.

I enjoy woodworking, yoga, and spinning.

I come from a big family; I am the oldest of six. When my wife and I tried to expand our family we turned to treatment and we now have twins from an injectable cycle. At the time, no one told me there was a 20 percent risk of twins. It makes me acutely sensitive to patients that say “I’m okay with twins.”

I think we do an amazing job at providing quality, evidence-based care, with attention to service and personalized to a patient’s needs.