Jeanne E. O’Brien, M.D.

Board Certified Board Certified

  • Obstetrics and Gynecology
  • Reproductive Endocrinology and Infertility
Patient Testimonial
Dr. O’Brien remained hopeful even after our first IVF cycle failed and now we are fortunate and grateful to have a son.

I was about to give up hope and another one of your patients recommended you. I am so grateful that I decided to come and meet with you.

Dr. O’Brien is not only an excellent doctor, she is also a good listener. I feel she is also a friend to me through my reproductive journey.

Dr. O’Brien is very well spoken, highly educated, kind, extremely diligent and thorough with all details. I trusted her 100% with advice during the donor selection process as well.

It isn’t possible to promise a perfect outcome, but Dr. O’Brien managed our expectations while remaining hopeful about success. We would highly recommend to anyone.

Dr. O’Brien made me feel like I was her only patient in the world. She spent all the time I needed to process what was happening with me and discussed a positive plan of action.

Dr. O’Brien was able to give me my daughter who is now 4, and is working her hardest to give us another child. I can’t thank her enough for everything she has done and will do for us.

Thank you from the bottom of my heart (and my heart-shaped uterus) for making such a beautiful home for 9 months for our little Luca.

You also allowed me to think that getting pregnant was a possibility. You never sugar-coated the odds or statistics, but you gave me something no other doctor had given me, and that was hope.

I hope you don’t ever see what you do as just employment. You truly are helping people’s dreams come true and for that, we are eternally grateful.


Jeanne E. O’Brien, M.D., received her medical degree from the Brown-Dartmouth Medical Program in Providence, RI, and completed her residency in obstetrics and gynecology at Prentice Women’s Hospital at Northwestern University in Chicago. In the 3 years following residency, Dr. O’Brien remained at Northwestern as a clinical instructor. She then completed fellowship training in reproductive endocrinology and infertility at Northwestern University and earned a master of science in clinical investigation. Dr. O’Brien is board certified in obstetrics and gynecology and reproductive endocrinology and infertility. She is a fellow of the American Congress of Obstetricians and Gynecologists, and a member of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility.

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The daily selfless contribution of the Shady Grove Fertility employees who collectively create a culture of compassion and excellence.


  • Residency: Obstetrics and Gynecology, Prentice Women’s Hospital at Northwestern University
  • Fellowship: Reproductive Endocrinology and Infertility, Northwestern University
  • Castle Connolly’s Top Doctors (2012-2013, 2016, 2022-2024)
  • Washingtonian’s Top Doctors for Infertility (2016-2023)
  • Patients’ Choice Award (2010-2012)
  • Compassionate Doctor Recognition (2010, 2012)
  • American Congress of Obstetricians and Gynecologists
  • American Society for Reproductive Medicine
  • Society for Reproductive Endocrinology and Infertility
  • Hewitt SC, O’Brien JE, Jameson JL, Kissling GE, Korach KS. Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Mol Endocrinol.2009;23(12):2111-6.
  • O’Brien JE, Peterson TJ, Tong MH, et al. Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements. J Biol Chem. 2006;281(36):26683-92.
  • O’Brien JE, Peterson ED, Keeler GP, et al. Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions. J Am Coll Cardiol. 1996;28(5):1111-8.


The daily selfless contribution of the Shady Grove Fertility employees who collectively create a culture of compassion and excellence.

I enjoy playing squash and hiking the local trails of the Potomac. Exercise is a great way to relax and enjoy time with my family.

The desire at every level to recognize and value the contribution of the individual employee toward the shared goal of helping patients achieve a family.

The Grand Canyon for a second time.

First listen to the individual, then make sure the patient understands how determined we are to help them achieve a family. The shared goal of achieving a successful pregnancy often requires more than one treatment cycle. It is a process that requires skill, mutual trust, and persistence. How you convey the knowledge and treatment plan are just as important as the information.