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Isaac E. Sasson, M.D., Ph.D.

Board Certified

  • Obstetrics and Gynecology
  • Reproductive Endocrinology and Infertility
945 Chesterbrook Boulevard
Chesterbrook, PA 19087
555 City Avenue
Suite 1170
Bala Cynwyd, PA 19004
6 Dickinson Drive
Building 300, Suite 311, 2nd Floor
Chadds Ford, PA 19317
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New Patient Appointments or 1.888.761.1967

About isaac e. sasson, M.D., ph.d.

Isaac E. Sasson, M.D., Ph.D., FACOG, received his medical degree and doctorate in genetics from Yale Medical School. He went on to complete his residency in obstetrics and gynecology at Yale-New Haven Hospital and his subspecialty training in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania in Philadelphia.

He has expertise in the diagnosis and treatment of infertility, including in vitro fertilization, donor egg treatment, endometriosis, polycystic ovary syndrome, and preimplantation genetic diagnosis. He utilizes both his clinical experience and extensive background in genetics research to optimize patient pregnancy and live birth rates.

Dr. Sasson has been featured in many publications, including Main Line Parent, Philadelphia Life, and Suburban Life. He has also appeared on The Katie Couric Show in a segment highlighting male factor infertility and on CBS 3 Philadelphia, where he discussed technological advancements in fertility treatment.

Originally from Monmouth County, New Jersey, Dr. Sasson is married with three children and enjoys yoga, spinning, hiking, and woodworking.

Dr. Sasson is currently associate residency director of ob-gyn residents at Lankenau Hospital outside of Philadelphia. He is a member of the American Society for Reproductive Medicine, American Congress of Obstetricians and Gynecologists, Obstetrical Society of Philadelphia, and Philadelphia Area Reproductive Endocrine Society.

  • Residency: Obstetrics and Gynecology, Yale-New Haven Hospital
  • Fellowship: Reproductive Endocrinology and Infertility, University of Pennsylvania
Awards & Recognition
  • Main Line Today magazine Top Doctors (2014-2015)
Professional Organizations
  • American Congress of Obstetricians and Gynecologists
  • American Society of Reproductive Medicine
  • Obstetrical Society of Philadelphia
  • Philadelphia Area Reproductive Endocrine Society

Q & A

Q: Why did you become a doctor?


My father is a pediatrician and the practice of medicine was always in our home. He works very hard, and growing up I always heard him on the phone with patients. He served as a role model when becoming an adult. So my connection to medicine is very connected to my family life at home.

Q: Who inspires you?


I am inspired by my patients’ strength. I am inspired by my kids’ thirst for knowledge, love, and experience. I am inspired by my medical school classmates. I am regularly amazed at how diverse they are and how much they have accomplished. I am inspired by the nursing staff at Shady Grove Fertility who are on the front line of patient care and are always working for perfection. I am inspired by my best friend, a lawyer on Capitol Hill. He is full of energy and enthusiasm and always looking for the next meaningful life experience. I think he is acutely aware that we only live once and that we need to make the most of every single day.

Q: What’s on your bucket list?


I want to lie on a beach in Tahiti, dive on the Great Barrier Reef, and go on safari in Africa.

Q: What are your hobbies?


I enjoy woodworking, yoga, and spinning.

Q: What about you would most surprise people?


I come from a big family; I am the oldest of six. When my wife and I tried to expand our family we turned to treatment and we now have twins from an injectable cycle. At the time, no one told me there was a 20 percent risk of twins. It makes me acutely sensitive to patients that say “I’m okay with twins.”

Q: What about SGF makes you the most proud?


I think we do an amazing job at providing quality, evidence-based care, with attention to service and personalized to a patient’s needs.

I am inspired by the nursing staff at Shady Grove Fertility who are on the front line of patient care and are always working for perfection.


"Hi Dr. Sasson, We didn't get to say goodbye and thank you since our 6 week appointment, so I just wanted to email you now that we've officially graduated and had our last appointment this week. Even though on paper you were not my primary doctor at Shady Grove, you certainly played a significant role in getting us pregnant - from retrieval to transfer! You have a way of putting me at ease, which is not a small task for an emotional basketcase such as yours truly. We avoided IVF for years due to my fear of the unknown, but it was such a relatively smooth process that we wish we had skipped all those IUIs and done it sooner. We have you, Dr. Munabi, and the entire staff to thank for that.
I hope that this pregnancy is a successful one and that we don't have to visit for a couple of years, as much as we will miss the great care we got with Shady Grove. We'll be back before you know it to transfer one of those beautiful blasts you helped us create."

"Dear Dr. Sasson,
Thank you so much for checking up on us in the OR on Friday. It meant the world to us as we were navigating this unexpected and difficult time. Our hopes were chewed up quite a bit and I was really emotional and a little irrational. Joe has been really supportive and I am feeling better about our hopes. I pray that God hasn’t forgotten us and your words gave us rays of hope on a very dark day. Thank you so much."

"Words cannot express the gratitude that we feel towards you for being the most supportive caring and compassionate doctor. Please know how much you have effected our lives and that we hold you in the highest regard and with all the love in our hearts."

"Dr. Sasson perfomed his duties with deep concern, professional knowledge, and exquisite sensitivity. Never have I know a doctor like Dr. Sasson."

"I just wanted to give our gratitude to you for the long talk last week when we came in to learn more about IVF and the donor egg process. We really felt comfortable and connected to you, personally. The thing that clicked for me was when you took the time, within our talk, to ask what our son's name was. It meant so much that you acknowledged him as a living and meaningful little soul rather than just an anonymous affected embryo. He is our world :-)"

"I wanted to thank you, Dr. Sasson, so much for meeting with us on Monday. I learned so much and was grateful to have met you. I am sad I did not find you earlier in our journey to have a baby. You are so kind and made us feel welcome in your office and not just another one of your patients. We cannot thank you enough."

"As I sit here with my 2 month old little boy sleeping on my lap, I can say that my experience with Dr. Sasson and Lisa Russell and the entire Shady Grove Fertility staff was exceptional. Having worked in the healthcare field as both a provder and administrator, I was continually impressed with the quality care I received from Dr. Sasson and everyone at the Chesterbrook and Bala Cynwyd offices. I went from being told I needed a hysterectomy from another physician in Reading, PA to holding my baby in my arms. I owe it all to Dr. Sasson. Can't say enough about him!!"

"Dr. Sasson and the entire staff at Shady Grove are exceptional. I could not ask for a more positive experience when dealing with infertility. My husband and I came to Shady Grove for unexplained recurrent pregnancy loss after another RE recommended that we simply keep trying. From our first meeting with Dr. Sasson he showed compassion for what we were going through, and he gave us honest advice as to what our best options were to achieve success. He is incredibly caring and always took the time to answer my questions and thoroughly explain things. His knowledge, his professionalism and his team made me feel at ease throughout our entire journey. Our wonderful nurse Lisa answered any questions we had and was always available by phone or email to guide us through the process. The entire Shady Grove team is very attentive. It was really comforting to be greeted by the same staff at each appointment. As happy as we are to have graduated to my Ob-gyn, it was very emotional to leave behind a group we have become so close to. Dr. Sasson and his staff are truly incredible and I would highly recommend them to anyone dealing with infertility. Thank You, Dr. Sasson, Lisa, Jami, Ted, Maria and Nina!!"

"We arrived in Dr. S's office after three years of trying to conceive and after being treated at two other clinics. Above all, he was an incredible listener and walked with us throughout our IVF cycles. We have a 2 year old whom Dr. S helped us achieve and we are now 14 weeks pregnant again with the help of SGF; I highly recommend Dr.S and Shady Grove Fertility."

"After 10 years of trying to conceive, many different Drs, many rounds of failed IVF and multiple miscarriages, I am now the Mom of a beautiful 5 week old baby girl thanks to Dr Sasson and his team. They are extremely skilled, competent, caring and compassionate. I never felt rushed when speaking with Dr. Sasson and I didn't feel like I was on a conveyer belt of patients which is how I felt at other practices. He took the time to consider all of my history and was always very encouraging while not giving false hope. I cannot recommend Dr. Sasson and Shady Grove Fertility enough."

"Dr. Sasson and his staff are simply the best. I felt a very personal connection with them, and when my procedure was successful, I knew they were as happy as I was. They are exceptional at what they do from a knowledge and capability standpoint AND the nicest, most caring people you're ever going to meet."

"He's the best. Dealing with infertility can be emotionally stressful, but he was very patient and answered all our questions and our concerns."



  • Sasson IE, Vitins AP, Mainigi MA, Moley KH, Simmons RA. Pre-gestational vs. gestational exposure to maternal obesity differentially programs the offspring in mice. Diabetologia. 2015;58:615-624.
  • Grissom NM, Lyde R, Christ L, et al. Obesity at conception programs the opioid system in the offspring brain. Neuropsychopharmacology. 2014;39:801-810.
  • Sasson I, Mesaros C, Bartolomei MS. Bisphenol A exposure alters DNA methylation and disrupts genomic imprinting in the mouse. PLoS Genetics. 2013;9:e1003401.
  • Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, et al. Embryonic poly(A) binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochem J. 2012;446:47-58.
  • Sasson IE, Kodaman PH. Adhesion prevention in gynecologic surgery. The Female Patient. 2008;33:1-5.
  • Johnson LN, Sasson IE, Sammel MD, Dokras A. Does intracytoplasmic sperm injection improve the fertilization rate and decrease the total fertilization failure rate in couples with well-defined unexplained infertility? A systematic review and meta-analysis. Fertil Steril. 2013;100:704-11.
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