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Research Publications

2020

2020 SGF Research Publications

Donor oocyte recipients do not benefit from preimplantation genetic testing for aneuploidy (PGT-A) to improve pregnancy outcomes. N Doyle, Mi Gainty, J Doyle, H Hayes, M Tucker, K Devine, A DeCherney, M Levy, S Jahandideh, MJ Hill. Human Reproduction. 2020.

An abnormal number of chromosomes in an embryo (either too many, or too few) will likely cause failed implantation or miscarriage. As a female enters her mid to late 30’s, the quality of her eggs begins to significantly decline, making conception and a resulting live birth, more difficult to achieve. For this reason, many women in this age group, using their own eggs, utilize PGT-A testing to identify chromosomally normal embryos for transfer, increasing their chances of success. In this study researchers found, PGT-A testing of embryos resulting from an egg donor, a women in her twenties with presumably higher quality eggs, did not improve the likelihood of live birth for recipients. This outcome suggests in many situations, embryo testing, with its additional time required and expense is not beneficial when using the egg of a donor.

Endometriosis does not impact live birth rates in frozen embryo transfers of euploid blastocysts. LA Bishop, J Gunn, S Jahandideh, K Devine, A DeCherney, MJ Hill. Fertil Steril. 2020.

The findings of this study demonstrate that the presence of Endometriosis alone does not impact the pregnancy or live birth rates in frozen embryo transfers nor does it impact the percentage of embryos that are chromosomally normal. This study looked at frozen embryo transfers using chromosomally normal (euploid) blastocyst stage embryos. The observation is significant for understanding the proper management of infertile women with endometriosis.

Does ovarian stimulation benefit ovulatory women undergoing therapeutic donor insemination? O Carpinello, S Jahandideh, M Yamasaki, MJ Hill, AH DeCherney, N Stentz, KS Moon, K Devine. Fertil Steril. 2020.

Natural cycle IUI should be considered as a first line treatment for women who ovulate regularly and plan to use donor sperm inseminations. This study shows ovarian stimulation in donor sperm insemination cycles, resulted in a < 4% increase in clinical pregnancy rates and < 1% increase in ongoing pregnancy. While the rates of ongoing pregnancy are similar to that of stimulated cycles, the chance of an ongoing multiple gestation pregnancy (twins or triplets) is four times higher.

The Utility of Sperm Cryopreservation at the Time of Vasectomy Reversal. J Marinaro, RP Hayden, P Shin, CJ Tanrikut. J Urol. 2020.


Cryopreservation of sperm at the time of vasectomy reversal should be routinely offered as a means of avoiding the added expense and potential side effects seen with surgical sperm retrieval. This study found of patients who experienced vasectomy reversal failure, 50% elected to use cryopreserved sperm that had been procured at the time of initial reversal.


Penile low intensity shock wave treatment for PDE5I refractory erectile dysfunction: a randomized double-blind sham-controlled clinical trial. J Vinay, D Moreno, O Rajmil, E Ruiz-Castañe, J Sanchez-Curbelo. World J Urol. 2020.

This study showed that penile electromagnetic shockwave therapy may improve erectile function, to a modest extent, on certain patients that do not respond to PDE5I (Viagra); making it an alternative for vascular erectile disfunction patients that reject more invasive therapies.

Is transferring a lower-quality embryo with a good-quality blastocyst detrimental to the likelihood of live birth? MJ Hill, AE Eubanks, JM Csokmay, AY Christy, S Jahandideh, AH DeCherney, K Devine, ED Levens, MT Connell. Fertil Steril. 2020;114(2):338-345.

Transferring a lower quality embryo along with a good-quality embryo at the same time, results in a small increase in live births. However, this is at the expense of an increased risk of the likelihood of multiples (twin, triplet) gestations

Post deployment Fertility Challenges and Treatment in the Modern Era. JA Lentscher, JC Combs, K Walker, CM Young, R Chason. Semin Reprod Med. 2019;37(5-06):239-245.

This review of fertility challenges in patients post military deployment, found, spinal cord injuries, traumatic brain injuries, and considerations unique to the female soldier resulted in the greatest occurrence of infertility.

Mature Follicle Count and Multiple Gestation Risk Based on Patient Age in Intrauterine Insemination Cycles With Ovarian Stimulation. MB Evans, NC Stentz, KS Richter, B Schexnayder, M Connell, MW Healy, K Devine, E Widra, R Stillman, AH DeCherney, MJ Hill. Obstet Gynecol. 2020;135(5):1005-1014.

Caution should be used in proceeding with insemination after ovarian stimulation when there are more than two mature follicles in women younger than age 40 years due to the substantially increased risk of multiple gestation without an improved chance of singleton clinical pregnancy.

The Role of the Urologist in a Reproductive Endocrinology and Infertility Practice. PJ Cheng, C Tanrikut. Urol Clin North Am. 2020;47(2):185-191.

This study found, when male factor infertility is part of an infertility diagnosis, selecting a fertility center with both reproductive urologist and reproductive endocrinologist allows for simultaneous treatment that is easier and more convenient for patients.

Public reporting of IVF outcomes influences medical decision-making and physician training. S Gunderson, ES Jungheim, CB Kallen, K Omurtag. Fertil Res Pract. 2020;6:1.



The intention of publicly reporting treatment outcomes (SART or CDC), is to drive improvement to fertility treatment, promote trust between patients and their medical providers, and inform consumers before selecting their fertility center of choice. This study found that public reporting of treatment outcomes, also resulted in providers modifying their practice, limited participation of trainees in procedures, and the perception that other physicians denied care to poor-prognosis patients in an attempt to have the best possible reported treatment outcomes.

Association between preoperative adenomyosis detection rate during pelvic ultrasonography and the Specialty of the Reading Physician. N Tamhane, M McDowell, M Oliva, JP Tanner, L Hochberg, M Baker M, A Imudia and E Mikhail. J Minim Invasive Gynecol. 2020;27(2):504-509.



Ultrasound evaluation for detecting adenomyosis should be performed by gynecologic expert sonologists. This study found, the detection rate of adenomyosis, a condition in which the inner lining of the uterus breaks through the muscle wall of the uterus, was significantly higher when ultrasound was performed by an expert gynecologic sonologists compared with radiologists. The presence of uterine fibroids, benign tumors of the uterus, significantly decreased detection rates of adenomyosis regardless of specialty.

Reproductive Health Needs of the Military and Veterans: Part 3. AY Christy, GL Mottla. Semin Reprod Med. 2020.

In part 3 of the Reproductive Needs of our Military and Veterans special issue, published in Seminars in Reproductive Medicine, researchers focus on the unique reproductive healthcare needs of the military and veterans, as well as the opportunities to advocate on behalf of all women who have worn the uniform.

"Don't We Take Care of Our Veterans?" The Critical Need for Veteran's Health Services Infertility Services for Veterans: Policies, Challenges, and Opportunities. L Woodruff, GL Mottla. Semin Reprod Med. 2020.

In this review article, published in Seminars in Reproductive Medicine, the researchers share compelling stories of military members and veterans who struggle with infertility. They also discuss the need for policy and expansion of services for infertility care in the Department of Defense and Veterans Health Administration, along with the challenges and opportunities that exist.

2019

2019 Research Publicatinos

Obstructive azoospermia secondary to bilateral epididymal cystadenomas in a patient with von Hippel-Lindau. PT Gomella, P Shin, R Srinivasan, WM Linehan, MW Ball. Urol Case Rep. 2019;27:100922.

Should we transfer monopronuclear embryos? More data and even more questions. MB Evans, MJ Hill, ED Levens. Fertil Steril. 2019;112(3):475-476.

Ambient Air Pollution Exposure and Fecundability in Women Undergoing In Vitro Fertilization. SM Quraishi, PC Lin, KS Richter, MD Hinckley, B Yee, G Neal-Perry, L Sheppard, JD Kaufman, A Hajat. Environ Epidemiol. 2019;3(1):e036.

Evaluation of an embryology and genetic testing patient counseling education intervention for reproductive endocrinology nurses. AB Catherino, C Halupa, FI Sharara, JG Bromer, B Hayward, WH Catherino. Fertil Steril. 2019;112(2):275-282.

Patient-centered elective egg freezing: a binational qualitative study of best practices for women's quality of care. MC Inhorn, D Birenbaum-Carmeli, LM Westphal, J Doyle, N Gleicher, D Meirow, M Dirnfeld, D Seidman, A Kahane, P Patrizio. J Assist Reprod Genet. 2019;36(6):1081-1090.

Larger oocyte cohorts maximize fresh IVF cycle birth rates and availability of surplus high-quality blastocysts for cryopreservation. MT Connell, KS Richter, K Devine, MJ Hill, AH DeCherney, JO Doyle, MJ Tucker, MJ Levy. Reprod Biomed Online. 2019;38(5):711-723.

Laparoscopic entry technique using Veress needle insertion with and without concomitant C02 insufflation, a Randomized Controlled Trial. E Mikhail, N Tamhane, P Sarkar, E Sappenfield, JP Tanner and AN Imudia. J Minim Invasive Gynecol. 2019;26(7):1383-1388.

Contemporary management of adnexa at the time of benign hysterectomy: a review of the literature. N Tamhane, A Imudia and E Mikhail. J Obstet Gynaecol. 2019;39(7):896-902.

Duration of gonadotropin stimulation is predictive of IVF outcomes. P Sarkar, L Ying, S Plosker, J Mayer, Y Ying and AN Imudia. Minerva Ginecol. 2019;71(6):419-426.

2018-2017


2018 Research Publications

    Defining thresholds for abnormal premature progesterone levels during ovarian stimulation for in vitro fertilization.
    MJ Hill, MW Healy, KS Richter, T Parikh, K Devine, AH DeCherney, MJ Levy, EA Widra, G Patounakis. Fertil Steril 2018;110:671-679. Read

    Diet and men's fertility: does diet affect sperm quality?
    FL Nassan, JE Chavarro, C Tanrikut. Fertil Steril 2018;110:570-77. Read

    Elective egg freezing and its underlying socio-demography: a binational analysis with global implications.
    MC Inhorn, D Birenbaum-Carmeli, J Birger, LM Westphal, J Doyle, N Gleicher, D Meirow, M Dirnfeld, D Seidman, A Kahane, P Patrizio. Reprod Biol Endocrinol 2018;16:70. Read

    Fraternal twins after elective single-embryo transfers: a lesson in never saying "never".
    CB Kallen. Fertil Steril 2018;109:63. Read

    I just can't do this anymore.
    EJ Mindes. Fertil Steril 2018;109:1018-9. Read

    Medical egg freezing: How cost and lack of insurance cover impact women and their families.
    MC Inhorn, D Birenbaum-Carmeli, LM Westphal, J Doyle, N Gleicher, D Meirow, H Raanani, M Dirnfeld, P Patrizio. Reprod Biomed Soc Online 2018;5:82-92. Read

    Medical egg freezing: the importance of a patient-centered approach to fertility preservation.
    MC Inhorn, D Birenbaum-Carmeli, LM Westphal, J Doyle, N Gleicher, D Meirow, H Raanani, M Dirnfeld, P Patrizio. J Assist Reprod Genet 2018;35:49-59. Read

    Optimal oocyte numbers: retrieval of larger cohorts maximizes fresh IVF cycle birth rates and potential for cryopreservation of surplus high-quality embryos.
    MT Connell, KS Richter, K Devine, MJ Hill, AH DeCherney, JO Doyle, MJ Tucker, MJ Levy. Reprod Biomed Online 2018 (in press)

    Ten pathways to elective egg freezing: a binational analysis.
    MC Inhorn, D Birenbaum-Carmeli, LM Westphal, J Doyle, N Gleicher, D Meirow, M Dirnfeld, D Seidman, A Kahane, P Patrizio. J Assist Reprod Genet 2018 (in press). Read

    Views of parents of children with sickle cell disease on pre-implantation genetic diagnosis.
    I Darbari, JE O’Brien, SJ Hardy, B Speller-Brown, L Thaniel, B Martin, DS Darbari, RS Nickel. Pediatric Blood Cancer 2018;65:e27102. Read

    Vitrified blastocyst transfer cycles with the use of only vaginal progesterone replacement with Endometrin have inferior ongoing pregnancy rates: results from the planned interim analysis of a three-arm randomized controlled noninferiority trial.
    K Devine, KS Richter, E Widra, JL McKeeby. Fertil Steril 2018;109:266-75. Read


    2017 research publications

    Diminished ovarian reserve as measured by means of baseline follicle-stimulating hormone and antral follicle count is not associated with pregnancy loss in younger in vitro fertilization patients.
    LA Bishop, KS Richter, G Patounakis, L Andriani, K Moon, K Devine. Fertil Steril 2017;108:980-7. Read

    Does elevated progesterone on day of oocyte maturation play a role in the racial disparities in IVF outcomes?
    MJ Hill, GD Royster, M Taneja, MW Healy, SM Zarek, AY Christy, AH DeCherney, E Widra, K Devine. Reprod Biomed Online 2017;154-61. Read

    Does premature elevated progesterone on the day of trigger increase spontaneous abortion rates in fresh and subsequent frozen embryo transfers?
    M Healy, G Patounakis, A Zanelotti, K Devine, A DeCherney, M Levy, MJ Hill. Gynecol Endocrinol 2017;33:472-5. Read

    Establishing an oocyte cryobank network.
    J Graham, J Lim, M Tucker. In: Cryopreservation of Mammilian Gametes and Embryos. Methods in Molecular Biology, Z Nagy, A Varghese, A Agarwal, eds. Humana Press 2017:195-203. Read

    Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates.
    A Wang, A Santistevan, K Hunter Cohen, A Copperman, J Nulsen, BT Miller, EA Widra, LM Westphal, P Yurttas Beim. Fertil Steril 2017;108:254-61 e4. Read

    Management of Chronic Pelvic Pain.
    LA Bishop. Clin Obstet Gynecol 2017;60:524-30. Read

    Revisting the progesterone to oocyte ratio.
    MJ Hill, MW Healy, KS Richter, E Widra, ED Levens, AH DeCherney, G Patounakis, B Whitcomb. Fertil Steril 2017;107:671-6 e2. Read

    The slow growing embryo and premature progesterone elevation: compounding factors for embryo-endometrial asynchrony.
    MW Healy, M Yamasaki, G Patounakis, KS Richter, K Devine, AH DeCherney, MJ Hill. Hum Reprod 2017;32:362-7. Read

ASRM ABSTRACTS

oral presentations

2020

Just over one-third of patients interested in embryo donation complete embryo donation. O Carpinello et al.

Psychobiological, clinical, and sociocultural factors that influence African American woman to seek treatment for infertility: A mixed methods study. M Cebert et al.

2019

Improving the REI fellowship interview experience: a survey. EP New et al.

2018

Lower gestational age and increased risk of preterm birth associated with singleton live birth resulting from in vitro fertilization (IVF) among African American versus comparable Caucasian women. LA Bishop et al.

Near futility of rescue intracytoplasmic sperm injection (ICSI) and the advantage of vitrification over fresh transfer. B Slocum et al.

Natural cycle intrauterine insemination (IUI) versus ovulation induction (OI) IUI for non-infertile women. O Carpinello et al.

Mature follicle count and multiple gestation risk based on patient age in ovulation induction-intrauterine insemination (OI-IUI) cycles. MB Evans et al.

Birth rates following euploid blastocyst transfer declines rapidly with previous unsuccessful transfers of euploid blastocysts. J Zolton et al.

2018 Scientific Congress Prize Paper - Three-arm RCT: vaginal only progesterone is inferior, but vaginal plus intramuscular (IM) progesterone every third day is equivalent, to daily IM progesterone for vitrified-warmed blastocyst transfer in terms of live birth. K Devine et al.

2018 Health Disparities Special Interest Group Prize Paper - African American patients experience reduced pregnancy, higher pregnancy loss, and lower live birth from IVF embryo transfers despite producing more oocytes and more transfer quality embryos than Caucasian patients. LA Bishop et al.

poster presentations

2020

Endometrial Receptivity Analysis (ERA) for patients with PGT-A normal frozen embryo transfers (FET): a retrospective analysis. JC Combs et al.

East Asian women experience lower rates of live birth than Caucasian women after single fresh blastocyst transfer but have similar outcomes after frozen transfer. AE Martini et al.

Promising live birth rates are seen with untested donated embryos. O Carpinello et al.

African American women have lower Odds of live birth from donor egg IVF. J Aly et al.

There is a disparity in ART outcomes between Asian and Caucasian woman in oocyte donation cycles. J Aly et al.

Does a low serum estradiol concentration prior to start of progesterone have an adverse effect on live birth in frozen embryo transfer cycles, even when endometrial double thickness is adequate? KAB Walker et al.

Obese patients are less likely to pursue fertility treatment and take a longer time to do so, after initial infertility consultation. AE Martini et al.

Correlation between endometrial thickness and probability of live birth in frozen blastocyst transfer cycles with and without pre-implantation genetic testing. RG Sprague et al.

Clarifying the relationship between total motile sperm counts (TMSC) and intrauterine insemination (IUI) pregnancy rates. A Muthigi et al.

Gestational carrier pregnancy outcomes from frozen embryo transfer (FET), depending on the number of embryos transferred and pre-implantation genetic testing: A retrospective analysis. A Namath et al.

Clinical barriers and facilitators that influence African American women to initiate treatment for infertility: A mixed methods study. M Cebert et al.

Preimplantation Genetic testing for Aneuploidy does not improve outcome in young patients undergoing IVF Treatment: A SART CORS study. P Sarkar et al.

Does Trophectoderm biopsy for Preimplantation Genetic Testing affect fetal birth weight or rate of preterm delivery? A SART CORS study. P Sarkar et al.

Prognostic value of low Anti-Mullerian hormone level during IVF among young women: A SART CORS study. P Sarkar et al.

Comparative analysis of FK506-binding proteins 51 (FKBP51) and 52 (FKBP52) in uterine fibroids compared to normal myometrium. EP New et al.

2019

Infertility patient clinical journey outcome depends on initial treatment, starting with ovulation induction (OI) vs in vitro fertilization (IVF): results from a large real-world database. M Mahony et al.

Insights into infertility patient discontinuation of care: results of a nationwide survey. B Collura et al.

Factors associated with a patient’s decision to discontinue fertility treatment before achieving pregnancy. B Collura et al.

α1D-Adrenergic Receptor Expression in Human Endometrial Stromal Cells Contributes to Catecholestradiol-induced Cell Survival: Implications for endometriosis. RG Sprague et al.

Propranolol Inhibition of Catecholestrogen-induced Human Endometrial Stromal Cell Survival is Mediated by p38 MAPK Cascade: Potential Therapy for Endometriosis. RG Sprague et al.

GATA Binding Protein 2 Expression at Implantation Window Diminishes in Women with Adenomyosis: Implications for Impaired Endometrial Receptivity. JW Kim et al.

2018

Euploid blastocysts undergoing single vitrification have higher live birth rates than those vitrified twice. K Devine et al.

The effect of vaginal misoprostol on patient reported pain during successive office hysteroscopy and endometrial biopsy. EP New et al.

The use of vaginal misoprostol prior to office hysteroscopy is associated with lower pain and tenaculum utilization during the procedure. P Sarkar et al.

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