SGFC for Preimplantation Genetics and Genetic Services

We are pleased to announce the addition of our state of the art Shady Grove Center for Preimplantation Genetics as an affiliate of Shady Grove Fertility Reproductive Science Centers and the addition of Dr. William G. Kearns as the program's Director. Dr. Kearns completed his Post Doctoral training in medical genetics at the highly respected Johns Hopkins McKusick-Nathan's Institute for Genetic Medicine. He comes to us now from a faculty position at Johns Hopkins and the NIH. We are extremely fortunate to have someone with his expertise and experience to lead us in this endeavor.

When is Preimplantation Genetic Diagnosis (PGD) indicated?
Genetic testing on pre-implantation embryos may be indicated for patients who are at risk for genetic disorders (e.g. Cystic fibrosis, Thalassemia) and for patients with infertility related to chromosomal abnormalities such as recurrent pregnancy loss or repeated unsuccessful IVF. Learn more...

The PGD Process
PGD testing is performed on a single blastomere from early dividing embryos in conjunction with an In Vitro Fertilization cycle. After the patient's eggs are retrieved, they are fertilized with the husband's sperm in the laboratory. Once fertilization occurs and embryos develop over the next 2 - 3 days to the 6-8-cell stage, one or two cells from each embryo are removed by the embryologists in our IVF Laboratory. The biopsied cells are immediately analyzed in the PGD Laboratory by sophisticated techniques such as fluorescence in situ hybridization (FISH) to determine proper structure for all chromosomes and appropriate number for chromosomes 13, 15,16, 17, 18, 21, 22, X and Y. DNA analysis is used for single gene defects, a partial listing of which is enclosed on the next page. Results are usually available within hours, well before the embryo would need to be transferred back into the uterus.

Benefits of PGD
As a result, for an increasing number of genetic disorders, PGD allows only those embryos identified as being free from the genetic disorder to be transferred for implantation and pregnancy. This provides great comfort for patients with genetic disorders who now may be able to transfer only normal embryos. It can also increase the likelihood of initiating a normal pregnancy in patients undergoing IVF.

Patient Referrals
If you believe you may be a candidate for Preimplantation Genetic Diagnosis or have more questions about testing for specific disorders, please don't hesitate to call one of our physicians. We would also encourage you to contact Dr. Kearns directly at 301-545-1260 at the Shady Grove Center for Preimplantation Genetic Diagnosis or by e-mail at William.Kearns@integramed.com.